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crosstalk 1

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piezoelectric (PZT) sensor networks 1

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Low crosstalk switch unit for dense piezoelectric sensor networks

Lei QIU, Shenfang YUAN,

Frontiers of Mechanical Engineering 2009, Volume 4, Issue 4, Pages 401-406 doi: 10.1007/s11465-009-0047-4

Abstract: Because of the high frequency and power of the lamb wave excitation signal, there exists a crosstalkA large crosstalk signal is mixed into the response signal so that the on/off-line signal processingThis paper first analyzes the crosstalk signal phenomenon, describes its production mechanism, and proposesThen a 24-switch channel low crosstalk switch unit based on a digital I/O board PCI7248 produced by AdlinkIts low crosstalk characteristics make it promote the real application of the SHM based active lamb wave

Keywords： structural health monitoring (SHM) piezoelectric (PZT) sensor networks switch unit crosstalk signal

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Control of lupus activity during pregnancy via the engagement of IgG sialylation: novel crosstalk between

Frontiers of Medicine 2023, Volume 17, Issue 3, Pages 549-561 doi: 10.1007/s11684-022-0965-7

Abstract: Immunoglobulin (IgG) glycosylation affects the effector functions of IgG in a myriad of biological processes and has been closely associated with numerous autoimmune diseases, including systemic lupus erythematosus (SLE), thus underlining the pathogenic role of glycosylation aberration in autoimmunity. This study aims to explore the relationship between IgG sialylation patterns and lupus pregnancy. Relative to that in serum samples from the control cohort, IgG sialylation level was aberrantly downregulated in serum samples from the SLE cohort at four stages (from preconception to the third trimester of pregnancy) and was significantly associated with lupus activity and fetal loss during lupus pregnancy. The type I interferon signature of pregnant patients with SLE was negatively correlated with the level of IgG sialylation. The lack of sialylation dampened the ability of IgG to suppress the functions of plasmacytoid dendritic cells (pDCs). RNA-seq analysis further revealed that the expression of genes associated with the spleen tyrosine kinase (SYK) signaling pathway significantly differed between IgG- and deSia-IgG-treated pDCs. This finding was confirmed by the attenuation of the ability to phosphorylate SYK and BLNK in deSia-IgG. Finally, the coculture of pDCs isolated from pregnant patients with SLE with IgG/deSia-IgG demonstrated the sialylation-dependent anti-inflammatory function of IgG. Our findings suggested that IgG influences lupus activity through regulating pDCs function via the modulation of the SYK pathway in a sialic acid-dependent manner.

Keywords： pregnancy IgG glycome type I interferon systemic lupus erythematosus